Sato, S.;...;Ukai, K. (2024.9, Chem Pharm Bull)[Understanding the Manufacturing Process of Lipid Nanoparticles for mRNA Delivery Using Machine Learning.] 理由 シンポジウムで紹介されてたので 概要 脂質ナノ粒子(LNPs)は、SARSコロナウイルス2に…

Axel Schmidt;...;Jochen Strube(2022.9, Processes)[Process Automation and Control Strategy by Quality-by-Design in Total Continuous mRNA Manufacturing Platforms] 概要 LNPでDOEの論文 概要 ワクチン供給は、必要な操作員や化学物質の製造キャパシ…

Gurba-Bryśkiewicz, L.;...; Wieczorek, M. (2023.10, Biomedicines) [Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery. ] 理由 LNPでDOEやりそうなので 概要 核酸の…

Sanne Bevers;...;Stefaan De Koker(2022.9, Molecular Therapy)[mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells] 理由 LNPでDoEしてる論文 概要 mRNAワクチンはSARS-CoV-2に対して…

Han Han Ly;....;Anna K. Blakney(2022.5, Molecular Pharmaceutics)[Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach] 理由 実験計画法使いそうなので 概要 脂質ナノ粒子(LNPs)…

Shaymaa A. Abd-algaleel;....;Rania M. Hathout(2021.7, Pharmaceuticals)[Evolution of the Computational Pharmaceutics Approaches in the Modeling and Prediction of Drug Payload in Lipid and Polymeric Nanocarriers] 理由 LNPへのモデリングの応用…

Wei Wang;...;Defang Ouyang(2022.6, Acta Pharmaceutica Sinica B)[Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm] 理由 機械学習の活用事例を知りたいので 概要 脂質ナノ粒子(LNP)はmRNAワクチンを届けるために…

Abdelkader A. Metwally; ...; Rania M. Hathout(2022.12, Front. Mol. Biosci.,)[In silico prediction of siRNA ionizable-lipid nanoparticles In vivo efficacy: Machine learning modeling based on formulation and molecular descriptors] 理由 将来…